RECRUITING

129 Xenon MRI As a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH and to determine the ability of 129Xe MRI to longitudinally monitor disease progression and response to therapy in PAH, with the aid of additional assessments, such as labs, echocardiography, and six-minute walk distance (6MWD).

Official Title

129 Xenon MRI As a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

Quick Facts

Study Start:2024-08-12
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06104228

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age: 18-75 years
  2. * WHO functional class 2 or 3
  3. * Mean pulmonary artery pressures \> 20 mmHg
  4. * Pulmonary capillary wedge pressure ≤15 mmHg
  5. * Pulmonary vascular resistance \> 2 Wood Units (WU)
  6. * No other cause identified for PAH
  7. * Age: 18-75 years
  8. * WHO functional class (FC) 2 or 3
  9. * Mean pulmonary artery pressures \> 20 mmHg
  10. * Pulmonary capillary wedge pressure ≤15 mmHg
  11. * Pulmonary vascular resistance \> 2 WU
  12. * Diagnosis of connective tissue disease
  1. * PH other than Idiopathic PAH or PAH associated with CTD; any conditions that prevent the performance of 129Xe MRI scans will be excluded from the study.

Contacts and Locations

Study Contact

David Ptashnik, MS
CONTACT
919-668-2642
david.ptashnik@duke.edu

Principal Investigator

Fawaz Alenezi, MD
PRINCIPAL_INVESTIGATOR
Duke Univeristy

Study Locations (Sites)

Duke University Medical Center
Durham, North Carolina, 27710
United States

Collaborators and Investigators

Sponsor: Bastiaan Driehuys

  • Fawaz Alenezi, MD, PRINCIPAL_INVESTIGATOR, Duke Univeristy

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-12
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2024-08-12
Study Completion Date2026-03-31

Terms related to this study

Additional Relevant MeSH Terms

  • Pulmonary Arterial Hypertension
  • Idiopathic Pulmonary Arterial Hypertension
  • Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (Disorder)
  • Connective Tissue Diseases