RECRUITING

RESISTance Exercise for Depression Trial

Description

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Conditions

Major Depressive Disorder
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Related Conditions:

Major Depressive Disorder

Study Overview

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Study Details

Study overview

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine

RESISTance Exercise for Depression Trial

Condition
Major Depressive Disorder
Intervention / Treatment

-

Contacts and Locations

Ames

Iowa State University, Ames, Iowa, United States, 50010

Madison

University of Wisconsin - Madison, Madison, Wisconsin, United States, 53705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be diagnosed with DSM-5 MDD, confirmed via Structured Clinical Interview for DSM-5 (SCID).
  • * Have current depressive symptoms of at least mild severity defined by the Hamilton Rating Scale of Depression 17 greater than or equal to 8 (HAMD; using the GRID-HAMD evaluated by trained, masked raters)
  • * Be ages 18-65
  • * EITHER not taking any mental health medications or seeking other mental health treatment (e.g., behavioral, psychological) OR be on a stable mental health medication and/or treatment regimen for the past 8 weeks, and intend to maintain that regimen for the duration of the study
  • * Safe to exercise based on physical activity screening questions or physician clearance
  • * Willing to be randomized to either condition
  • * have a Smartphone
  • * Currently pregnant, nursing, or planning to become pregnant during the trial
  • * Class III+ obesity
  • * Diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID
  • * Diagnosed with current Substance Use Disorder, via the SCID
  • * Active suicidal ideation with specific plan and intent ('5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale), which would necessitate immediate emergent care
  • * Exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, as assessed by clinical research personnel
  • * Currently meets resistance exercise recommendations (2 days per week) for the last 8 weeks
  • * Self-reporting a concussion/traumatic brain injury within the last 3 months
  • * Having cardiovascular disease, uncontrolled hypertension, or uncontrolled diabetes

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Wisconsin, Madison,

Jacob Meyer, PhD, PRINCIPAL_INVESTIGATOR, University of Wisconsin, Madison

Study Record Dates

2028-05-31