RESISTance Exercise for Depression Trial

Description

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Conditions

Major Depressive Disorder

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Study Overview

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Study Details

Study overview

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine

RESISTance Exercise for Depression Trial

Condition
Major Depressive Disorder
Intervention / Treatment

-

Contacts and Locations

Ames

Iowa State University, Ames, Iowa, United States, 50010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be diagnosed with DSM-5 MDD, confirmed via Structured Clinical Interview for DSM-5 (SCID).
  • * Have current depressive symptoms of at least mild severity defined by the Hamilton Rating Scale of Depression 17 greater than or equal to 8 (HAMD; using the GRID-HAMD evaluated by trained, masked raters)
  • * Be ages 18-65
  • * EITHER not taking any mental health medications or seeking other mental health treatment (e.g., behavioral, psychological) OR be on a stable mental health medication and/or treatment regimen for the past 8 weeks, and be willing to maintain that regimen for the duration of the study
  • * Safe to exercise based on physician clearance
  • * Willing to be randomized to either condition
  • * Currently pregnant, nursing, or planning to become pregnant during the trial
  • * Class III+ obesity
  • * Diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID
  • * Diagnosed with current Substance Use Disorder, via the SCID
  • * Active suicidal ideation with specific plan and intent ('5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale), which would necessitate immediate emergent care
  • * Exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, as assessed by clinical research personnel
  • * Currently meets resistance exercise recommendations (2 days per week) for the last 8 weeks
  • * Concussion/traumatic brain injury within the last 3 months

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Iowa State University,

Study Record Dates

2028-05-31