RECRUITING

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

Official Title

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Quick Facts

Study Start:2024-05-13
Study Completion:2025-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06127342

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 64 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults with PTSD related to interpersonal violence
  1. * Active or recent (within the last 3 months) severe substance use disorder(s)
  2. * Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
  3. * Significant developmental disabilities
  4. * Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
  5. * Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
  6. * Medical condition(s) that prohibit exercise
  7. * History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins
  8. * Magnetic resonance imaging (MRI) contraindication(s)
  9. * Positive pregnancy test
  10. * History of seizure disorder
  11. * Spontaneous seizure(s) within the last 3 months

Contacts and Locations

Study Contact

Christal G Badour, PhD
CONTACT
859-323-3817
christal.badour@uky.edu

Principal Investigator

Thomas G Adams, Jr., PhD
PRINCIPAL_INVESTIGATOR
University of Kentucky
Christal Badour, PhD
PRINCIPAL_INVESTIGATOR
University of Kentucky

Study Locations (Sites)

University of Kentucky
Lexington, Kentucky, 40506
United States
University of Texas
Austin, Texas, 78712
United States

Collaborators and Investigators

Sponsor: Christal L Badour

  • Thomas G Adams, Jr., PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky
  • Christal Badour, PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-13
Study Completion Date2025-11-30

Study Record Updates

Study Start Date2024-05-13
Study Completion Date2025-11-30

Terms related to this study

Keywords Provided by Researchers

  • Interpersonal Violence
  • Exercise

Additional Relevant MeSH Terms

  • PTSD