Exercise and Emotional Learning in Posttraumatic Stress Disorder

Description

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

Conditions

PTSD

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Condition
PTSD
Intervention / Treatment

-

Contacts and Locations

Lexington

University of Kentucky, Lexington, Kentucky, United States, 40506

Austin

University of Texas, Austin, Texas, United States, 78712

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults with PTSD related to interpersonal violence
  • * Active or recent (within the last 3 months) severe substance use disorder(s)
  • * Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
  • * Significant developmental disabilities
  • * Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
  • * Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
  • * Medical condition(s) that prohibit exercise
  • * History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins
  • * Magnetic resonance imaging (MRI) contraindication(s)
  • * Positive pregnancy test
  • * History of seizure disorder
  • * Spontaneous seizure(s) within the last 3 months

Ages Eligible for Study

18 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Christal L Badour,

Thomas G Adams, Jr., PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Christal Badour, PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

2025-11-30