RECRUITING

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

Official Title

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Quick Facts

Study Start:2024-01-08
Study Completion:2026-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06128915

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Both sexes
  2. * Have not been vaccinated with any licensed or experimental pneumococcal vaccine
  3. * Ages 21-40; and ≥65. Individuals \>60 years old will also be recruited in case we find no unvaccinated people ≥65 years old
  4. * Free of acute infections within the last 2 weeks
  5. * Did not take any anti-inflammatory medicine in the last week
  6. * Did not ingest alcohol in the last 24 hours
  7. * Ability and willingness to provide consent
  1. * Previous vaccination with any licensed or experimental pneumococcal vaccine
  2. * Known hypersensitivity to vaccination and vaccine components
  3. * Immune deficiency
  4. * Use of immune-modulating or suppressive drugs
  5. * Malignancies within the last 2 years
  6. * Known hematological, rheumatic and inflammatory diseases
  7. * Known chronic infections
  8. * Poorly controlled chronic cardiovascular and metabolic conditions
  9. * Pregnancy
  10. * Dementia

Contacts and Locations

Study Contact

Elsa Bou Ghanem, PhD
CONTACT
7168292422
elsaboug@buffalo.edu

Principal Investigator

Elsa N Bou Ghanem, PhD
PRINCIPAL_INVESTIGATOR
University at Buffalo

Study Locations (Sites)

University at Buffalo
Buffalo, New York, 14203
United States

Collaborators and Investigators

Sponsor: State University of New York at Buffalo

  • Elsa N Bou Ghanem, PhD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-08
Study Completion Date2026-05-31

Study Record Updates

Study Start Date2024-01-08
Study Completion Date2026-05-31

Terms related to this study

Keywords Provided by Researchers

  • Aging
  • Neutrophils
  • Streptococcus pneumoniae
  • Pneumococcal conjugate vaccine

Additional Relevant MeSH Terms

  • Aging