The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Description

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

Conditions

Aging

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Study Overview

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Study Details

Study overview

This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Buffalo

University at Buffalo, Buffalo, New York, United States, 14203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Both sexes
  • * Have not been vaccinated with any licensed or experimental pneumococcal vaccine
  • * Ages 21-40; and ≥65. Individuals \>60 years old will also be recruited in case we find no unvaccinated people ≥65 years old
  • * Free of acute infections within the last 2 weeks
  • * Did not take any anti-inflammatory medicine in the last week
  • * Did not ingest alcohol in the last 24 hours
  • * Ability and willingness to provide consent
  • * Previous vaccination with any licensed or experimental pneumococcal vaccine
  • * Known hypersensitivity to vaccination and vaccine components
  • * Immune deficiency
  • * Use of immune-modulating or suppressive drugs
  • * Malignancies within the last 2 years
  • * Known hematological, rheumatic and inflammatory diseases
  • * Known chronic infections
  • * Poorly controlled chronic cardiovascular and metabolic conditions
  • * Pregnancy
  • * Dementia

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

State University of New York at Buffalo,

Elsa N Bou Ghanem, PhD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

2026-05-31