RECRUITING

AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.

Official Title

AvoCog - The Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Quick Facts

Study Start:2024-04-09
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06137339

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Males and females aged 65-85 years
  2. * Good general health with no concomitant disease
  3. * BMI 18.5 - 35 kg/m2
  4. * Mini Mental State Exam ≥26
  5. * Reports consuming ≤2 medium avocados per month
  6. * Reports consuming ≤3 servings of carotenoid-rich foods per week and ≤3 servings of fruits and vegetables per day
  7. * Skin carotenoid content \<400
  1. * Unwilling or unable to consume avocado
  2. * Latex allergy
  3. * Consistently taking lutein + zeaxanthin supplements
  4. * Skin carotenoid content ≥400
  5. * Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
  6. * Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
  7. * Diabetes mellitus or uncontrolled hypertension
  8. * Use of psychoactive or investigational medications
  9. * Consumption of ≥3 alcoholic drinks per day or substance abuse
  10. * Unable to undergo MRI

Contacts and Locations

Study Contact

Emma Kelly, MS
CONTACT
913-588-7683
ekelly9@kumc.edu
Matthew Taylor, PhD
CONTACT
913-588-5363
mtaylor3@kumc.edu

Study Locations (Sites)

University of Kansas Medical Center
Kansas City, Kansas, 66160
United States

Collaborators and Investigators

Sponsor: University of Kansas Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-09
Study Completion Date2025-12

Study Record Updates

Study Start Date2024-04-09
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • Older Adults
  • Brain Health
  • Avocado
  • Brain Imaging
  • Cognition
  • Dietary Intervention

Additional Relevant MeSH Terms

  • Brain Aging