AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Description

The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.

Conditions

Brain Aging

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.

AvoCog - The Effect of Daily Avocado Intake on Cognitive Function in Older Adults

AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults

Condition
Brain Aging
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Males and females aged 65-85 years
  • * Good general health with no concomitant disease
  • * BMI 18.5 - 35 kg/m2
  • * Mini Mental State Exam ≥26
  • * Reports consuming ≤2 medium avocados per month
  • * Reports consuming ≤3 servings of carotenoid-rich foods per week and ≤3 servings of fruits and vegetables per day
  • * Skin carotenoid content \<400
  • * Unwilling or unable to consume avocado
  • * Latex allergy
  • * Consistently taking lutein + zeaxanthin supplements
  • * Skin carotenoid content ≥400
  • * Central neurological disease such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, brain tumor, etc.
  • * Serious medical risk: cancer requiring chemotherapy or radiation within the past 5 years, recent cardiac event (i.e. heart attack, etc.)
  • * Diabetes mellitus or uncontrolled hypertension
  • * Use of psychoactive or investigational medications
  • * Consumption of ≥3 alcoholic drinks per day or substance abuse
  • * Unable to undergo MRI

Ages Eligible for Study

65 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Kansas Medical Center,

Study Record Dates

2025-12