RECRUITING

Impact of Atelectasis on RVEDP Following Orthotropic Heart Transplantation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant treatment regiments. These procedures are done under general anesthesia which promotes lung tissue collapse (atelectasis). What is not known is the effect of atelectasis on intracardiac pressures which are a critical area of monitoring post-transplant patients for rejection.

Official Title

Impact of Atelectasis and Lung Recruitment on RVEDP Measurement in Children Undergoing Cardiac Catheterization for Surveillance Following Orthotropic Heart Transplantation

Quick Facts

Study Start:2023-11-20
Study Completion:2024-11-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06140810

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients having undergone orthotropic heart transplantation
  2. * Patients requiring routine heart catheterization for post-transplant surveillance
  3. * General anesthesia
  1. * Patient/parental refusal
  2. * Patients with suspected or known acute rejection
  3. * Known anti-rejection medication non-compliance
  4. * Patients within 1 year following heart transplant
  5. * Home oxygen requirement
  6. * Previous lung surgery (e.g., lobectomy) other than biopsy
  7. * Lung transplantation
  8. * Known pulmonary fibrosis
  9. * Known pulmonary hypertension (\>1/2 systemic)
  10. * Sedation without the use of an airway device
  11. * Active respiratory infection -Inability to provide recruitment breaths \>25mmHg -Cardiomegaly
  12. * Recipient/donor size mismatch

Contacts and Locations

Study Contact

Adam Adler, MD
CONTACT
8328245800
adam.adler@bcm.edu

Principal Investigator

adam adker, MD
PRINCIPAL_INVESTIGATOR
Texas Childrens Hospital

Study Locations (Sites)

Texas Childrens Hospital
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Baylor College of Medicine

  • adam adker, MD, PRINCIPAL_INVESTIGATOR, Texas Childrens Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-20
Study Completion Date2024-11-01

Study Record Updates

Study Start Date2023-11-20
Study Completion Date2024-11-01

Terms related to this study

Additional Relevant MeSH Terms

  • Heart Transplant Failure
  • Anesthesia