Impact of Atelectasis on RVEDP Following Orthotropic Heart Transplantation

Description

Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant treatment regiments. These procedures are done under general anesthesia which promotes lung tissue collapse (atelectasis). What is not known is the effect of atelectasis on intracardiac pressures which are a critical area of monitoring post-transplant patients for rejection.

Conditions

Heart Transplant Failure, Anesthesia

Study Overview

Study Details

Study overview

Following orthoptopic heart transplantation (OHT), children undergo surveillance cardiac catheterizations to assess for signs of rejection including muscle biopsy as well as pressure measurements to guide post transplant treatment regiments. These procedures are done under general anesthesia which promotes lung tissue collapse (atelectasis). What is not known is the effect of atelectasis on intracardiac pressures which are a critical area of monitoring post-transplant patients for rejection.

Impact of Atelectasis and Lung Recruitment on RVEDP Measurement in Children Undergoing Cardiac Catheterization for Surveillance Following Orthotropic Heart Transplantation

Impact of Atelectasis on RVEDP Following Orthotropic Heart Transplantation

Condition
Heart Transplant Failure
Intervention / Treatment

-

Contacts and Locations

Houston

Texas Childrens Hospital, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients having undergone orthotropic heart transplantation
  • * Patients requiring routine heart catheterization for post-transplant surveillance
  • * General anesthesia
  • * Patient/parental refusal
  • * Patients with suspected or known acute rejection
  • * Known anti-rejection medication non-compliance
  • * Patients within 1 year following heart transplant
  • * Home oxygen requirement
  • * Previous lung surgery (e.g., lobectomy) other than biopsy
  • * Lung transplantation
  • * Known pulmonary fibrosis
  • * Known pulmonary hypertension (\>1/2 systemic)
  • * Sedation without the use of an airway device
  • * Active respiratory infection -Inability to provide recruitment breaths \>25mmHg -Cardiomegaly
  • * Recipient/donor size mismatch

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Baylor College of Medicine,

adam adker, MD, PRINCIPAL_INVESTIGATOR, Texas Childrens Hospital

Study Record Dates

2024-11-01