RECRUITING

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The FeMicrobiome study will evaluate gut microbiome features and their relationships with dietary iron absorption in healthy adults. The investigators hypothesize that (1) the gut microbiota can be shaped by the heme and non-heme Fe content of the diet and that (2) this will influence individual variation in dietary Fe absorption.

Official Title

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Quick Facts

Study Start:2023-01-15
Study Completion:2026-01-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06146608

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Healthy adults
  2. * Age between 18- 40y
  3. * Non-smoking
  4. * Not currently taking vitamin, mineral, prebiotic, and probiotic supplements.
  5. * Females: premenopausal and not pregnant or lactating
  6. * No preexisting medical complications (such as eating disorders, hemoglobinopathies, malabsorption diseases, steroid use, substance abuse history, or taking medications known to influence iron homeostasis)
  7. * Body mass index (BMI) between 18 - 27 kg/m2.
  1. * BMI \<18 or \> 27 kg/m2,
  2. * Age \<18 y or \> 40y,
  3. * Not of Northern European or East Asian ancestry
  4. * Smoking
  5. * Pregnancy, lactating
  6. * Have gastrointestinal disorders/malabsorption diseases/hemoglobinopathies/dietary restrictions/steroid use/ medication use of medications known to impact iron status, iron utilization or inflammatory status
  7. * Currently take vitamin, mineral, prebiotic, and probiotic supplements.
  8. * Recently received antibiotic treatment

Contacts and Locations

Study Contact

Kimberly O O'Brien, PhD
CONTACT
607-255-3743
koo4@cornell.edu

Principal Investigator

KIMBERLY ORA OBRIEN, PhD
PRINCIPAL_INVESTIGATOR
Cornell University

Study Locations (Sites)

Cornell University
Ithaca, New York, 14853
United States

Collaborators and Investigators

Sponsor: Cornell University

  • KIMBERLY ORA OBRIEN, PhD, PRINCIPAL_INVESTIGATOR, Cornell University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-15
Study Completion Date2026-01-14

Study Record Updates

Study Start Date2023-01-15
Study Completion Date2026-01-14

Terms related to this study

Additional Relevant MeSH Terms

  • Anemia, Iron Deficiency
  • Iron Overload