Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Description

The FeMicrobiome study will evaluate gut microbiome features and their relationships with dietary iron absorption in healthy adults. The investigators hypothesize that (1) the gut microbiota can be shaped by the heme and non-heme Fe content of the diet and that (2) this will influence individual variation in dietary Fe absorption.

Conditions

Anemia, Iron Deficiency, Iron Overload

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Study Overview

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Study Details

Study overview

The FeMicrobiome study will evaluate gut microbiome features and their relationships with dietary iron absorption in healthy adults. The investigators hypothesize that (1) the gut microbiota can be shaped by the heme and non-heme Fe content of the diet and that (2) this will influence individual variation in dietary Fe absorption.

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption

Condition
Anemia, Iron Deficiency
Intervention / Treatment

-

Contacts and Locations

Ithaca

Cornell University, Ithaca, New York, United States, 14853

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy adults
  • * Age between 18- 40y
  • * Non-smoking
  • * Not currently taking vitamin, mineral, prebiotic, and probiotic supplements.
  • * Females: premenopausal and not pregnant or lactating
  • * No preexisting medical complications (such as eating disorders, hemoglobinopathies, malabsorption diseases, steroid use, substance abuse history, or taking medications known to influence iron homeostasis)
  • * Body mass index (BMI) between 18 - 27 kg/m2.
  • * BMI \<18 or \> 27 kg/m2,
  • * Age \<18 y or \> 40y,
  • * Not of Northern European or East Asian ancestry
  • * Smoking
  • * Pregnancy, lactating
  • * Have gastrointestinal disorders/malabsorption diseases/hemoglobinopathies/dietary restrictions/steroid use/ medication use of medications known to impact iron status, iron utilization or inflammatory status
  • * Currently take vitamin, mineral, prebiotic, and probiotic supplements.
  • * Recently received antibiotic treatment

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Cornell University,

KIMBERLY ORA OBRIEN, PhD, PRINCIPAL_INVESTIGATOR, Cornell University

Study Record Dates

2026-01-14