RECRUITING

Effect of Genetic Polymorphisms on the Clinical Response to SGLT2 Inhibitors in Heart Failure Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown further reductions in heart failure hospitalization, cardiovascular events, and mortality, especially for heart failure patients. The SGLT2 gene, also known as SLC5A2 (solute carrier family 5 member 2), is located on chromosome 16 and is responsible for encoding SGLT2. Several SLC5A2 mutations alter SGLT2 expression, membrane location, or transporter function. Several common genetic variations were found in the SLC5A2 gene that may affect the response to treatment with SGLT2 inhibitors.

Official Title

Effect of Genetic Polymorphisms on the Clinical Response to Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors in Prevention of Cardiac Remodeling and Fibrosis in Heart Failure Patients

Quick Facts

Study Start:2023-12-27
Study Completion:2024-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06201000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Heart failure patients NYHA class II to III.
  2. * Heart failure patients with reduced left ventricular ejection fraction (LVEF) \< 45% or with preserved left ventricular ejection fraction (LVEF) \> 45%
  3. * Patients who will be candidate for add-on treatment with SGLT2.
  4. * Patients who will be able to sign informed consent to participate in the study.
  1. * Contraindications to SGLT2.
  2. * Significant coronary artery diseases (CAD), coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or valve surgery within 3 months.
  3. * Pregnant or breastfeeding women.
  4. * Patients with estimated glomerular filtration rates less than 30 mL/min/1.73 m2, as determined using the CKD-EPI equation.

Contacts and Locations

Study Contact

Ahmed Essam, MSc
CONTACT
+201007647696
ahmed.essam@o6u.edu.eg

Principal Investigator

Rania Sarhan, PhD
STUDY_DIRECTOR
Beni-Suef University
Neven Sarhan, PhD
STUDY_DIRECTOR
Misr International University
Bassem Zarif, MD
STUDY_DIRECTOR
National Heart Institute
Julio Duarte, PhD
STUDY_CHAIR
University of Florida

Study Locations (Sites)

University of Florida
Gainesville, Florida, 32610
United States

Collaborators and Investigators

Sponsor: October 6 University

  • Rania Sarhan, PhD, STUDY_DIRECTOR, Beni-Suef University
  • Neven Sarhan, PhD, STUDY_DIRECTOR, Misr International University
  • Bassem Zarif, MD, STUDY_DIRECTOR, National Heart Institute
  • Julio Duarte, PhD, STUDY_CHAIR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-12-27
Study Completion Date2024-09-01

Study Record Updates

Study Start Date2023-12-27
Study Completion Date2024-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Genetic Polymorphisms
  • Heart Failure