RECRUITING

Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Some participants will train on a treadmill in the laboratory for up to two sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. Other participants will train outside the laboratory for one session with 30 minutes of walking with feedback to investigate changes in knee loading while using the new walking strategy during over-ground walking. The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.

Official Title

Effects of Haptic Movement Retraining on Osteoarthritis Progression

Quick Facts

Study Start:2024-01-18
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06208631

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Medial and/or lateral compartment knee osteoarthritis
  2. * Diagnosed with knee osteoarthritis of at least six months duration
  3. * Ambulatory without aids
  4. * Able to walk for at least 60 minutes
  5. * Typical pain rating less than or equal to 4 on scale of 0-10
  6. * Able to reduce gastrocnemius muscle activation by 10% from baseline
  1. * History of symptomatic arthritis in lower limb joints other than the knees
  2. * Replacement of any lower extremity joint
  3. * Symptoms originating from the patellofemoral joint
  4. * Body mass index equal to or greater than 35
  5. * Nerve or muscle disease associated with walking difficulty
  6. * History of rheumatoid arthritis, gout, or autoimmune disease
  7. * History of lower limb fracture or surgery requiring hospitalization
  8. * Pregnant

Contacts and Locations

Study Contact

Study Team
CONTACT
650-721-2547
oawalking@lists.stanford.edu

Principal Investigator

Scott L Delp, PhD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford Human Performance Lab
Stanford, California, 94305
United States

Collaborators and Investigators

Sponsor: Stanford University

  • Scott L Delp, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-18
Study Completion Date2026-12

Study Record Updates

Study Start Date2024-01-18
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Osteoarthritis, Knee