Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

Description

This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Participants will train for up to three sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. An exploratory third session may be conducted to investigate changes in knee loading while using the new walking strategy during over-ground walking. The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.

Conditions

Osteoarthritis, Knee

Study Overview

Study Details

Study overview

This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Participants will train for up to three sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. An exploratory third session may be conducted to investigate changes in knee loading while using the new walking strategy during over-ground walking. The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.

Effects of Haptic Movement Retraining on Osteoarthritis Progression

Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

Condition
Osteoarthritis, Knee
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford Human Performance Lab, Stanford, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Medial and/or lateral compartment knee osteoarthritis
  • * Diagnosed with knee osteoarthritis of at least six months duration
  • * Ambulatory without aids
  • * Able to walk for at least 60 minutes
  • * Typical pain rating less than or equal to 4 on scale of 0-10
  • * Able to reduce gastrocnemius muscle activation by 10% from baseline
  • * History of symptomatic arthritis in lower limb joints other than the knees
  • * Replacement of any lower extremity joint
  • * Symptoms originating from the patellofemoral joint
  • * Body mass index equal to or greater than 35
  • * Nerve or muscle disease associated with walking difficulty
  • * History of rheumatoid arthritis, gout, or autoimmune disease
  • * History of lower limb fracture or surgery requiring hospitalization
  • * Pregnant
  • * Severe knee malalignment, defined as a hip-knee-ankle angle of more than 5 degrees from neutral
  • * Recurrent giving way of the knee

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Scott L Delp, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2024-12