RECRUITING

Neural and Cognitive Consequences of COVID-19 Survival

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.

Official Title

Neural and Cognitive Consequences of COVID-19 Survival

Quick Facts

Study Start:2021-10-01
Study Completion:2025-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06208943

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
  2. * Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner.
  3. * 18-70 years with a confirmed COVID infection at least 3 months ago.
  4. * Negative metal screen for MRI safety
  5. * Normal (or corrected to normal) vision
  1. * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms)
  2. * Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms
  3. * Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
  4. * Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions
  5. * Known claustrophobia
  6. * Current pregnancy
  7. * IQ estimate \< 70

Contacts and Locations

Study Contact

Kaitlyn L Dal Bon, BA
CONTACT
(415) 629-9514
kaitlyn.dalbon@ucsf.edu
Ken Lau, BS
CONTACT
(415) 562-4334
ken.lau@ucsf.edu

Principal Investigator

Judith M Ford, PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

San Francisco Heathcare System
San Francisco, California, 94121
United States

Collaborators and Investigators

Sponsor: San Francisco Veterans Affairs Medical Center

  • Judith M Ford, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-01
Study Completion Date2025-09-30

Study Record Updates

Study Start Date2021-10-01
Study Completion Date2025-09-30

Terms related to this study

Keywords Provided by Researchers

  • EEG
  • fMRI
  • MRI
  • functional MRI
  • brain fog
  • long COVID
  • fatigue
  • difficulty concentrating
  • memory difficulty

Additional Relevant MeSH Terms

  • COVID Long-Haul
  • COVID-19
  • COVID-19 Pandemic
  • Brain Fog
  • Memory Deficits
  • Concentration Ability Impaired
  • Fatigue