Neural and Cognitive Consequences of COVID-19 Survival

Description

The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.

Conditions

COVID Long-Haul, COVID-19, COVID-19 Pandemic, Brain Fog, Memory Deficits, Concentration Ability Impaired, Fatigue

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Study Overview

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Study Details

Study overview

The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.

Neural and Cognitive Consequences of COVID-19 Survival

Neural and Cognitive Consequences of COVID-19 Survival

Condition
COVID Long-Haul
Intervention / Treatment

-

Contacts and Locations

San Francisco

San Francisco Heathcare System, San Francisco, California, United States, 94121

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
  • * Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner.
  • * 18-70 years with a confirmed COVID infection at least 3 months ago.
  • * Negative metal screen for MRI safety
  • * Normal (or corrected to normal) vision
  • * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms)
  • * Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms
  • * Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
  • * Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions
  • * Known claustrophobia
  • * Current pregnancy
  • * IQ estimate \< 70

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

San Francisco Veterans Affairs Medical Center,

Judith M Ford, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2025-09-30