RECRUITING

Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS.

Official Title

Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder Using Transcranial Magnetic Stimulation

Quick Facts

Study Start:2024-04-03
Study Completion:2027-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06214065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Estimated full-scale IQ\>80
  2. * Right handed
  3. * Fluent in English
  4. * Individual can cooperate with all study's procedures
  5. * No history of neurological disorder (e.g. epilepsy) or neurosurgery
  6. * No major medical condition (e.g. cancer, heart failure)
  7. * No history of significant head injury
  8. * No primary relatives with history of any neurological disorder with a potentially hereditary basis, including epilepsy or MS
  9. * No current use of medications with psychotropic (e.g., benzodiazepines) or anti- or pro-convulsants
  10. * No current substance use (determined by urine screen and breathalyzer in all visits)
  11. * Negative urine pregnancy (women) test at time of MRI scans
  12. * No MR contra-indications (e.g. in-body metal implant, severe claustrophobia)
  13. * No previous participation in our lab in a study including the Domino fMRI task
  14. * For ASD: Stable medication treatment 4 weeks prior to study enrollment
  15. * For Control Group: No current or history of psychiatric disorders, other than simple phobia, and/or primary relatives with ASD
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Michal Assaf, MD
CONTACT
860-545-7792
michal.assaf@hhchealth.org
Vaughn R Steele, MD
CONTACT
860-545-7855
vaughn.steele@yale.edu

Principal Investigator

Vaughn Steele, MD
PRINCIPAL_INVESTIGATOR
Yale University
Michal Assaf, MD
PRINCIPAL_INVESTIGATOR
Yale University

Study Locations (Sites)

Olin Neuropsychiatry Research Center (ONRC)
Hartford, Connecticut, 06106
United States

Collaborators and Investigators

Sponsor: Yale University

  • Vaughn Steele, MD, PRINCIPAL_INVESTIGATOR, Yale University
  • Michal Assaf, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-03
Study Completion Date2027-10

Study Record Updates

Study Start Date2024-04-03
Study Completion Date2027-10

Terms related to this study

Keywords Provided by Researchers

  • Transcranial Magnetic Stimulation

Additional Relevant MeSH Terms

  • Autism Spectrum Disorder