Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

Description

The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS.

Conditions

Autism Spectrum Disorder

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Study Overview

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Study Details

Study overview

The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS.

Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder Using Transcranial Magnetic Stimulation

Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Hartford

Olin Neuropsychiatry Research Center (ONRC), Hartford, Connecticut, United States, 06106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Estimated full-scale IQ\>80
  • * Right handed
  • * Fluent in English
  • * Individual can cooperate with all study's procedures
  • * No history of neurological disorder (e.g. epilepsy) or neurosurgery
  • * No major medical condition (e.g. cancer, heart failure)
  • * No history of significant head injury
  • * No primary relatives with history of any neurological disorder with a potentially hereditary basis, including epilepsy or MS
  • * No current use of medications with psychotropic (e.g., benzodiazepines) or anti- or pro-convulsants
  • * No current substance use (determined by urine screen and breathalyzer in all visits)
  • * Negative urine pregnancy (women) test at time of MRI scans
  • * No MR contra-indications (e.g. in-body metal implant, severe claustrophobia)
  • * No previous participation in our lab in a study including the Domino fMRI task
  • * For ASD: Stable medication treatment 4 weeks prior to study enrollment
  • * For Control Group: No current or history of psychiatric disorders, other than simple phobia, and/or primary relatives with ASD

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Vaughn Steele, MD, PRINCIPAL_INVESTIGATOR, Yale University

Michal Assaf, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2027-10