RECRUITING

EEG Changes Related to taVNS in Stroke Patients: a Preliminary Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In the United States, more than 795,000 people have a stroke every year. Motor impairment after a stroke is common and can be debilitating. To date, there remain few treatments available to help improve motor recovery after a stroke, making this an important area of research. Novel use of neuromodulation such as Invasive Vagus Nerve Stimulation (VNS) has been shown to improve motor recovery in stroke patients. Vagus nerve stimulation (VNS), in which the nerve is stimulated with electrical pulses, has demonstrated success for a variety of conditions, including inflammation, depression, cognitive dysfunction, chronic fatigue, headaches/migraines, pain, insomnia, and cardiovascular issues. Very recently, non-invasive options have been developed and might be a promising alternative. The research in this area is still very limited and much more research is needed to investigate non-invasive/trancutaneous auricular vagus nerve stimulation (taVNS) related biomechanisms and to further support its efficacy in acute patients. The purpose of this study is to build upon the current research to investigate changes in electrical brain activity (using electrophysiology) related to improvements in both motor and cognitive recovery following the use of taVNS in acute stroke patients.

Official Title

EEG Changes Related to Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Acute Stroke Patients: a Preliminary Study

Quick Facts

Study Start:2024-01-29
Study Completion:2025-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06226493

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * First-time Cerebrovascular Accident (Ischemic or Hemorrhagic)
  2. * Within a month post-injury
  1. * Advanced cardiac, pulmonary, liver, or kidney disease
  2. * Bradycardia (Resting HR \< 60)
  3. * Presence of Apraxia, Aphasia or confusion
  4. * Other musculoskeletal or neurologic diseases that could interfere with the outcome measures
  5. * Previous surgical intervention on the vagus nerve
  6. * Participation in other clinical trials
  7. * Alcohol or drug abuse

Contacts and Locations

Study Contact

Caroline Schnakers, PhD
CONTACT
(909)596-7733
cschnakers@casacolina.org
Niko Fullmer, BS
CONTACT
(909)596-7733
nfullmer@casacolina.org

Principal Investigator

Elliott Block, MD
PRINCIPAL_INVESTIGATOR
Casa Colina Hospital and Centers for Healthcare

Study Locations (Sites)

Casa Colina Hospital and Centers for Healthcare
Pomona, California, 91769
United States

Collaborators and Investigators

Sponsor: Casa Colina Hospital and Centers for Healthcare

  • Elliott Block, MD, PRINCIPAL_INVESTIGATOR, Casa Colina Hospital and Centers for Healthcare

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-29
Study Completion Date2025-06-30

Study Record Updates

Study Start Date2024-01-29
Study Completion Date2025-06-30

Terms related to this study

Keywords Provided by Researchers

  • vagus nerve stimulation
  • electrophysiology

Additional Relevant MeSH Terms

  • Stroke