RECRUITING

Post-Concussion Differences Between Buffalo Concussion Treadmill Test (BCTT) and Modified Dynamic Exertion (mEXiT) Test

Conditions

Mild Traumatic Brain Injury mtbi concussion exertion therapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to compare symptom provocation, physiologic response, and rate of perceived (RPE) between the Buffalo Concussion Treadmill Test (BCTT) and a Modified Dynamic Exertion (mEXiT) test after sport related concussion in adolescents aged 14-17. Participants will be enrolled at their initial concussion clinical visit within 14 days of their injury, and randomly assigned to either the BCTT or mEXiT group. Participants will complete a single visit.

Official Title

Comparing Symptom Provocation and Physiological Response Between Buffalo Concussion Treadmill Test (BCTT) Protocol and Modified Dynamic Exertion Test (mEXiT) Post Concussion

Quick Facts

Study Start:2024-03-05

Study Completion:2025-03-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06276660

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years to 17 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:CHILD

Inclusion Criteria	Exclusion Criteria
* Diagnosed with a sport related concussion within 14 days of injury * Participants referred to exertion therapy after a trained clinician from University of Pittsburgh Medical Center (UPMC) Sports Medicine Concussion Program has interpreted neurocognitive, vestibular, and clinical interview outcomes and determined the participant is capable of completing structured exercise.	* Medically cleared from a previous concussion within the past 6 months * More than 2 previous concussions (excluding current injury) * History of brain surgery or traumatic brain injury (TBI) (based on Glasgow Coma Scale of \<13) * History of neurological disorder (seizure disorder, epilepsy, brain tumors or malformations) * Current history of pre-existing vestibular disorder or oculomotor condition * Currently taking antidepressant, anticoagulant, beta-blocker, or anticonvulsant prescription medications * Incapable of treadmill running up to 5.5 miles per hour (mph) and 4.5 mph for males and females respectively (self-reported). * Diagnosed with a cardiac, peripheral, or cerebrovascular disease (type 1 or 2 diabetes, or renal disease. * Experienced chest pain or shortness of breath while at rest or with mild exertion. * Lose balance because of dizziness or have lost consciousness (aside from concussion) from exertion * Currently have (or have had within the past 12 months) a bone, joint, or soft tissue (muscle, ligament, or tendon) problem that could be made worse by physical activity * Been told by a doctor to only conduct physical activity under medical supervision.

Inclusion Criteria

Exclusion Criteria

* Diagnosed with a sport related concussion within 14 days of injury
* Participants referred to exertion therapy after a trained clinician from University of Pittsburgh Medical Center (UPMC) Sports Medicine Concussion Program has interpreted neurocognitive, vestibular, and clinical interview outcomes and determined the participant is capable of completing structured exercise.

* Medically cleared from a previous concussion within the past 6 months
* More than 2 previous concussions (excluding current injury)
* History of brain surgery or traumatic brain injury (TBI) (based on Glasgow Coma Scale of \<13)
* History of neurological disorder (seizure disorder, epilepsy, brain tumors or malformations)
* Current history of pre-existing vestibular disorder or oculomotor condition
* Currently taking antidepressant, anticoagulant, beta-blocker, or anticonvulsant prescription medications
* Incapable of treadmill running up to 5.5 miles per hour (mph) and 4.5 mph for males and females respectively (self-reported).
* Diagnosed with a cardiac, peripheral, or cerebrovascular disease (type 1 or 2 diabetes, or renal disease.
* Experienced chest pain or shortness of breath while at rest or with mild exertion.
* Lose balance because of dizziness or have lost consciousness (aside from concussion) from exertion
* Currently have (or have had within the past 12 months) a bone, joint, or soft tissue (muscle, ligament, or tendon) problem that could be made worse by physical activity
* Been told by a doctor to only conduct physical activity under medical supervision.

Contacts and Locations

Study Contact

Anthony P Kontos, PhD

CONTACT

412-904-1298

akontos@pitt.edu

Sarah Ostop, DPT

CONTACT

724-720-3050

sterlingse@upmc.edu

Principal Investigator

Anthony P Kontos, PhD

PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Study Locations (Sites)

UPMC/Univ of Pgh Sports Medicine Concussion Research Program

Pittsburgh, Pennsylvania, 15203

United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

Anthony P Kontos, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-05

Study Completion Date2025-03-31

Study Record Updates

Study Start Date2024-03-05

Study Completion Date2025-03-31

Terms related to this study

Keywords Provided by Researchers

mtbi
concussion
exertion therapy

Additional Relevant MeSH Terms

Mild Traumatic Brain Injury