RECRUITING

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

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Conditions

Postural Orthostatic Tachycardia Syndrome

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Official Title

Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1

Quick Facts

Study Start:2024-03-05
Study Completion:2029-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06292104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥ 14 years, able to provide informed consent (assent with parental consent for age \< 18) and comply with procedures
  2. * Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) \>120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate \< 100 bpm, (5) orthostatic symptoms present for at least 6 months
  3. * Stable oral medication regimen for at least 14 days
  4. * Healthy women, age 18 - 30 years, able to provide informed consent and comply with study procedures
  5. * Does NOT meet consensus criteria for postural tachycardia syndrome
  6. * No symptoms of orthostatic intolerance or dysautonomia. No history of other major medical disorder
  7. * Resting supine heart rate \< 100 bpm
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Steve Hopkins
CONTACT
214-648-9275
steve.hopkins@utsouthwestern.edu

Principal Investigator

Steven Vernino, MD PhD
PRINCIPAL_INVESTIGATOR
UT Southwestern Medical Center

Study Locations (Sites)

UT Southwestern Medical Center
Dallas, Texas, 75208
United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

  • Steven Vernino, MD PhD, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-05
Study Completion Date2029-01

Study Record Updates

Study Start Date2024-03-05
Study Completion Date2029-01

Terms related to this study

Additional Relevant MeSH Terms

  • Postural Orthostatic Tachycardia Syndrome