Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Description

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Conditions

Postural Orthostatic Tachycardia Syndrome

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Study Overview

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Study Details

Study overview

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1

Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Condition
Postural Orthostatic Tachycardia Syndrome
Intervention / Treatment

-

Contacts and Locations

Dallas

UT Southwestern Medical Center, Dallas, Texas, United States, 75208

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 14 years, able to provide informed consent (assent with parental consent for age \< 18) and comply with procedures
  • * Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) \>120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate \< 100 bpm, (5) orthostatic symptoms present for at least 6 months
  • * Stable oral medication regimen for at least 14 days
  • * Healthy women, age 18 - 30 years, able to provide informed consent and comply with study procedures
  • * Does NOT meet consensus criteria for postural tachycardia syndrome
  • * No symptoms of orthostatic intolerance or dysautonomia. No history of other major medical disorder
  • * Resting supine heart rate \< 100 bpm

Ages Eligible for Study

14 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Steven Vernino, MD PhD, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

2029-01