RECRUITING

Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Official Title

A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release

Quick Facts

Study Start:2024-09-16
Study Completion:2032-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06330545

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 45 or greater with DC
  2. * Extension deficit \>10 degrees
  3. * Unable to simultaneously place the affected finger and palm flat on a table.
  4. * Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
  5. * For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included
  1. * Unsuccessful non-surgical release (\> N/1 disease)
  2. * They develop an open wound during CCH
  3. * Breast feeding or pregnancy
  4. * A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
  5. * Less than the age of 45
  6. * They have previously undergone radiation on the hand in which they plan to get CCH injections
  7. * They are pregnant women, impaired adults or prisoners

Contacts and Locations

Study Contact

Julia S Schwarz, MD
CONTACT
603 650-5133
julia.s.schwarz@hitchcock.org
Lance Warhold, MD
CONTACT
603 650-5133

Principal Investigator

Lance Warhold, MD
PRINCIPAL_INVESTIGATOR
Dartmouth Health

Study Locations (Sites)

Dartmouth Hitchcock
Lebanon, New Hampshire, 03766
United States

Collaborators and Investigators

Sponsor: Dartmouth-Hitchcock Medical Center

  • Lance Warhold, MD, PRINCIPAL_INVESTIGATOR, Dartmouth Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-16
Study Completion Date2032-04

Study Record Updates

Study Start Date2024-09-16
Study Completion Date2032-04

Terms related to this study

Keywords Provided by Researchers

  • Dupuytren's contracture
  • radiation therapy

Additional Relevant MeSH Terms

  • Dupuytren Contracture