Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Description

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Conditions

Dupuytren Contracture

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Study Overview

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Study Details

Study overview

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release

Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Condition
Dupuytren Contracture
Intervention / Treatment

-

Contacts and Locations

Lebanon

Dartmouth Hitchcock, Lebanon, New Hampshire, United States, 03766

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 45 or greater with DC
  • * Extension deficit \>10 degrees
  • * Unable to simultaneously place the affected finger and palm flat on a table.
  • * Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
  • * For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included
  • * Unsuccessful non-surgical release (\> N/1 disease)
  • * They develop an open wound during CCH
  • * Breast feeding or pregnancy
  • * A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
  • * Less than the age of 45
  • * They have previously undergone radiation on the hand in which they plan to get CCH injections
  • * They are pregnant women, impaired adults or prisoners

Ages Eligible for Study

45 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Dartmouth-Hitchcock Medical Center,

Lance Warhold, MD, PRINCIPAL_INVESTIGATOR, Dartmouth Health

Study Record Dates

2032-04