RECRUITING

Ventilatory Parameters in Predicting Outcomes in ARDS Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation

Official Title

Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20/Cdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation

Quick Facts

Study Start:2023-06-01
Study Completion:2025-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06400095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:19 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with Acute respiratory failure needing mechanical ventilation
  2. * Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5
  1. * r2 \< 0.95, monitored on the ventilator
  2. * Expiratory flow that is not first-order or non-exponential decay
  3. * Patients with Nor-epinephrine requirements \> 0.1 mcg/kg/min within 2 hours of intubation
  4. * Patients requiring ECMO ( Extracorporeal membrane oxygenation)
  5. * Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \< 1.5 L
  6. * Severe atherosclerotic vascular disease
  7. * Patients with a chest tube, intra-abdominal hypertension or with its risk factors
  8. * Patients with structural heart disease including pulmonary hypertension (RVSP \> 45) and heart failure
  9. * All comfort care orders in the ICU
  10. * Patients who underwent tracheostomy

Contacts and Locations

Study Contact

Ramakanth Pata, MD FCCP
CONTACT
320-240-2207
cookybrey1@gmail.com

Principal Investigator

Ramakanth Pata, MD FCCP
PRINCIPAL_INVESTIGATOR
Centracare health System

Study Locations (Sites)

St Cloud Hospital
Saint Cloud, Minnesota, 56303
United States

Collaborators and Investigators

Sponsor: CentraCare

  • Ramakanth Pata, MD FCCP, PRINCIPAL_INVESTIGATOR, Centracare health System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-01
Study Completion Date2025-07

Study Record Updates

Study Start Date2023-06-01
Study Completion Date2025-07

Terms related to this study

Keywords Provided by Researchers

  • Expiratory time constant
  • Ventilator ratio
  • Cdyn/C20
  • Occlusion pressure at 100 msec

Additional Relevant MeSH Terms

  • ARDS
  • Mechanical Power