Ventilatory Parameters in Predicting Outcomes in ARDS Patients

Description

This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation

Conditions

ARDS, Mechanical Power

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Study Overview

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Study Details

Study overview

This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation

Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20/Cdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation

Ventilatory Parameters in Predicting Outcomes in ARDS Patients

Condition
ARDS
Intervention / Treatment

-

Contacts and Locations

Saint Cloud

St Cloud Hospital, Saint Cloud, Minnesota, United States, 56303

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with Acute respiratory failure needing mechanical ventilation
  • * Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5
  • * r2 \< 0.95, monitored on the ventilator
  • * Expiratory flow that is not first-order or non-exponential decay
  • * Patients with Nor-epinephrine requirements \> 0.1 mcg/kg/min within 2 hours of intubation
  • * Patients requiring ECMO ( Extracorporeal membrane oxygenation)
  • * Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \< 1.5 L
  • * Severe atherosclerotic vascular disease
  • * Patients with a chest tube, intra-abdominal hypertension or with its risk factors
  • * Patients with structural heart disease including pulmonary hypertension (RVSP \> 45) and heart failure
  • * All comfort care orders in the ICU
  • * Patients who underwent tracheostomy

Ages Eligible for Study

19 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

CentraCare,

Ramakanth Pata, MD FCCP, PRINCIPAL_INVESTIGATOR, Centracare health System

Study Record Dates

2025-07