RECRUITING

Chronic Lung Allograft Dysfunction MRI Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Official Title

Validation of MRI, CT and Pulmonary Function Tests for Early Detection of Chronic Lung Allograft Dysfunction

Quick Facts

Study Start:2025-03-20
Study Completion:2028-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06406777

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ages 18-80
  2. * English Speaking Subjects
  3. * Willingness and ability to provide informed consent
  4. * Non-smoker
  1. * SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing
  2. * Unilateral diaphragm paralysis
  3. * Evidence of acute illness on day of study
  4. * Evidence of restrictive lung disease
  5. * Dependence on supplemental oxygen
  6. * History of cardiac disease
  7. * Pregnancy (self-declared)
  8. * Lactating women
  9. * Participants with metal objects in their body
  10. * Known contraindication to MRI examination
  11. * Systolic blood pressure reading of \< 100 mmHg or \> 200 mmHg
  12. * Diastolic blood pressure reading of \<60 mmHg or \> 100 mmHg

Contacts and Locations

Study Contact

Sean Fain, Ph.D.
CONTACT
319 356 4832
sean-fain@uiowa.edu

Principal Investigator

Sean Fain, Ph.D
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

University of Iowa
Iowa City, Iowa, 52242
United States

Collaborators and Investigators

Sponsor: Sean Fain

  • Sean Fain, Ph.D, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-20
Study Completion Date2028-09

Study Record Updates

Study Start Date2025-03-20
Study Completion Date2028-09

Terms related to this study

Keywords Provided by Researchers

  • Lung Transplant

Additional Relevant MeSH Terms

  • Chronic Lung Allograft Dysfunction Lung MRI (CLAD)