Chronic Lung Allograft Dysfunction MRI Study

Description

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Conditions

Chronic Lung Allograft Dysfunction Lung MRI (CLAD)

Talk to us

Study Overview

On this page

Study Details

Study overview

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Validation of MRI, CT and Pulmonary Function Tests for Early Detection of Chronic Lung Allograft Dysfunction

Chronic Lung Allograft Dysfunction MRI Study

Condition
Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18-80
  • * English Speaking Subjects
  • * Willingness and ability to provide informed consent
  • * Non-smoker
  • * SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing
  • * Unilateral diaphragm paralysis
  • * Evidence of acute illness on day of study
  • * Evidence of restrictive lung disease
  • * Dependence on supplemental oxygen
  • * History of cardiac disease
  • * Pregnancy (self-declared)
  • * Lactating women
  • * Participants with metal objects in their body
  • * Known contraindication to MRI examination
  • * Systolic blood pressure reading of \< 100 mmHg or \> 200 mmHg
  • * Diastolic blood pressure reading of \<60 mmHg or \> 100 mmHg

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Sean Fain,

Sean Fain, Ph.D, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2028-09