RECRUITING

Rebuilding Inter-limb Transfer in Cervical SCI

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Conditions

Cervical Spinal Cord InjuryUpper limbMotor TrainingBrain StimulationPeripheral Nerve StimulationHand DexterityInter-limb transferMotor learning

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic motor and hand dexterity skills.

Official Title

Improving Upper Limb Rehabilitation by Rebuilding Inter-limb Transfer of Motor Gains in Cervical SCI

Quick Facts

Study Start:2024-02-15
Study Completion:2025-07-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06440538

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Neurological Level of Injury C4, C5, C6, C7, C8
  2. * American Spinal Injury Association Impairment Scale (AIS) C-D
  3. * greater than or equal to 1 year time post injury
  4. * residual motor sparing of bilateral FDI muscles, defined as medical research council (MRC) grade 2 to 5
  1. * contraindications to transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) including pacemaker, metal in the skull, seizure history, pregnancy, etc.
  2. * history of alcohol and/or drug abuse
  3. * current usage of medications that can potentially lower the seizure threshold such as bupropion, amphetamines, etc.
  4. * history of other neurological conditions such as stroke, Parkinson's, and traumatic brain injury (TBI)
  5. * active pressure ulcers to avoid disruption of ongoing medical treatments
  6. * participation of on-going upper-limb therapies to minimize confounding effects
  7. * excessive tone/spasticity (Modified Ashworth Scale \[MAS\] \>3) and severe contractures or soft tissue shortening at elbow/wrist/fingers

Contacts and Locations

Study Contact

Kyle J O'Laughlin, MS
CONTACT
216-445-6728
olaughk@ccf.org
Jia Liu, PhD
CONTACT
216-445-6728
LIUJ19@ccf.org

Principal Investigator

Ela Plow, PhD
PRINCIPAL_INVESTIGATOR
The Cleveland Clinic

Study Locations (Sites)

Lerner Research Institute; Cleveland Clinid Foundation
Cleveland, Ohio, 44195
United States

Collaborators and Investigators

Sponsor: The Cleveland Clinic

  • Ela Plow, PhD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-15
Study Completion Date2025-07-30

Study Record Updates

Study Start Date2024-02-15
Study Completion Date2025-07-30

Terms related to this study

Keywords Provided by Researchers

  • Cervical Spinal Cord Injury
  • Upper limb
  • Motor Training
  • Brain Stimulation
  • Peripheral Nerve Stimulation
  • Hand Dexterity
  • Inter-limb transfer
  • Motor learning

Additional Relevant MeSH Terms

  • Cervical Spinal Cord Injury