Rebuilding Inter-limb Transfer in Cervical SCI

Description

The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic motor and hand dexterity skills.

Conditions

Cervical Spinal Cord Injury

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Study Overview

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Study Details

Study overview

The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic motor and hand dexterity skills.

Improving Upper Limb Rehabilitation by Rebuilding Inter-limb Transfer of Motor Gains in Cervical SCI

Rebuilding Inter-limb Transfer in Cervical SCI

Condition
Cervical Spinal Cord Injury
Intervention / Treatment

-

Contacts and Locations

Cleveland

Lerner Research Institute; Cleveland Clinid Foundation, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Neurological Level of Injury C4, C5, C6, C7, C8
  • * American Spinal Injury Association Impairment Scale (AIS) C-D
  • * greater than or equal to 1 year time post injury
  • * residual motor sparing of bilateral FDI muscles, defined as medical research council (MRC) grade 2 to 5
  • * contraindications to transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) including pacemaker, metal in the skull, seizure history, pregnancy, etc.
  • * history of alcohol and/or drug abuse
  • * current usage of medications that can potentially lower the seizure threshold such as bupropion, amphetamines, etc.
  • * history of other neurological conditions such as stroke, Parkinson's, and traumatic brain injury (TBI)
  • * active pressure ulcers to avoid disruption of ongoing medical treatments
  • * participation of on-going upper-limb therapies to minimize confounding effects
  • * excessive tone/spasticity (Modified Ashworth Scale \[MAS\] \>3) and severe contractures or soft tissue shortening at elbow/wrist/fingers

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The Cleveland Clinic,

Ela Plow, PhD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2025-07-30