RECRUITING

Role of Aging and Individual Variation in Exercise Training Responsiveness

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Conditions

Prediabetic StateCardiovascular DiseasesInsulin ResistanceObesityExerciseCardiorespiratory FitnessFunctional CapacityCardiometabolic RiskPhysical ReservePhysical Resilience

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 26 participants to complete a 6-month aerobic exercise intervention.

Official Title

The Role of Aging and Individual Variation in Exercise Training Responsiveness

Quick Facts

Study Start:2025-04-02
Study Completion:2027-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06471569

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
  2. * Body Mass Index (BMI) \> 18 and \< 45 kg/m2
  3. * Stable dose (≥1 month) of any cardiometabolic medications
  1. * Poor vein access
  2. * Current use of tobacco or any nicotine products, including e-cigarettes
  3. * Insulin-dependent diabetes
  4. * Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations \> 10.0 uIU/mL
  5. * Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
  6. * Current, actively treated malignancy other than dermatologic conditions
  7. * Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
  8. * Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
  9. * Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
  10. * Unable to safely participate in an exercise program per study protocol per PI discretion
  11. * Planned, intentional weight loss during study

Contacts and Locations

Study Contact

Johanna L Johnson, MS
CONTACT
9196606766
johanna.johnson@duke.edu
Leanna M Ross, PhD
CONTACT
9196606688
leanna.ross@duke.edu

Principal Investigator

Leanna M Ross, PhD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Duke Center for Living
Durham, North Carolina, 27705
United States

Collaborators and Investigators

Sponsor: Duke University

  • Leanna M Ross, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-02
Study Completion Date2027-03-31

Study Record Updates

Study Start Date2025-04-02
Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

  • Exercise
  • Cardiorespiratory Fitness
  • Functional Capacity
  • Cardiometabolic Risk
  • Physical Reserve
  • Physical Resilience

Additional Relevant MeSH Terms

  • Prediabetic State
  • Cardiovascular Diseases
  • Insulin Resistance
  • Obesity