Role of Aging and Individual Variation in Exercise Training Responsiveness

Description

The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 8 participants to complete a 6-month aerobic exercise intervention.

Conditions

Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity

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Study Overview

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Study Details

Study overview

The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 8 participants to complete a 6-month aerobic exercise intervention.

The Role of Aging and Individual Variation in Exercise Training Responsiveness

Role of Aging and Individual Variation in Exercise Training Responsiveness

Condition
Prediabetic State
Intervention / Treatment

-

Contacts and Locations

Durham

Duke Center for Living, Durham, North Carolina, United States, 27705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
  • * Body Mass Index (BMI) \> 18 and \< 45 kg/m2
  • * Stable dose (≥1 month) of any cardiometabolic medications
  • * Poor vein access
  • * Current use of tobacco or any nicotine products, including e-cigarettes
  • * Insulin-dependent diabetes
  • * Active untreated hyper or hypothyroidism with thyroid stimulating hormone (TSH) concentrations \< 1.5 or \> 10.0 uIU/mL
  • * Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
  • * Current, actively treated malignancy other than dermatologic conditions
  • * Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
  • * Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
  • * Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
  • * Unable to safely participate in an exercise program per study protocol per PI discretion
  • * Planned, intentional weight loss during study

Ages Eligible for Study

60 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Leanna M Ross, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2026-03-15