RECRUITING

Night Owl Metabolism

Description

The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.

Conditions

PreDiabetesOverweightImpaired Glucose Tolerance
Talk to us

Related Conditions:

PreDiabetesOverweightImpaired Glucose Tolerance

Study Overview

On this page

Study Details

Study overview

The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.

Night Owl Metabolism: Investigating the Impact of Chronotype on Glucose Metabolism in Youth

Night Owl Metabolism

Condition
PreDiabetes
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used))
  • * Post-pubertal
  • * Normal sleep duration (avg. \>7 hours of sleep per night)
  • * Social jetlag (difference between weekend and weekday sleep) of \< 2 hours.
  • * Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
  • * Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
  • * Screening high risk for obstructive sleep apnea
  • * Night shift work.

Ages Eligible for Study

18 Years to 23 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Talia Hitt, MD/MPH/MSHP, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2030-01-31