Night Owl Metabolism

Description

The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.

Conditions

PreDiabetes, Overweight, Impaired Glucose Tolerance

Talk to us

Study Overview

On this page

Study Details

Study overview

The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.

Night Owl Metabolism: Investigating the Impact of Chronotype on Glucose Metabolism in Youth

Night Owl Metabolism

Condition
PreDiabetes
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used))
  • * Post-pubertal
  • * Normal sleep duration (avg. \>7 hours of sleep per night)
  • * Social jetlag (difference between weekend and weekday sleep) of \< 2 hours.
  • * Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
  • * Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
  • * Screening high risk for obstructive sleep apnea
  • * Night shift work.

Ages Eligible for Study

18 Years to 23 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Talia Hitt, MD/MPH/MSHP, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2030-01-31