RECRUITING

FMRI Accelerated TMS Depression

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Official Title

Tracking Brain Imaging Changes in Depression Over Clinical Accelerated Transcranial Magnetic Stimulation (TMS) Therapy At the Individual Level

Quick Facts

Study Start:2024-09-23
Study Completion:2026-08-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06562153

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-65
  2. * Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
  3. * DSM-IV diagnosis of MDD
  1. * Unable to speak English.
  2. * Contraindicated for MRI.
  3. * Any current or recent untreated medical, neurological, or psychiatric conditions
  4. * Metal implant devices in the head, heart, or neck.
  5. * History of brain surgery.
  6. * History of cortisol medication use or electroconvulsive therapy.
  7. * Comorbidity with other psychiatric/neurological illnesses or personality disorders
  8. * History of myocardial infarction or arrhythmia, bradycardia.
  9. * Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
  10. * Individuals suffering from frequent/severe headaches.
  11. * Moderate to severe alcohol or substance use disorder.
  12. * Pregnancy

Contacts and Locations

Study Contact

Katherine Tucker
CONTACT
843-792-9502
tuckekat@musc.edu

Principal Investigator

Xiaolong Peng
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

30 Bee Street
Charleston, South Carolina, 29429
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Xiaolong Peng, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-23
Study Completion Date2026-08-05

Study Record Updates

Study Start Date2024-09-23
Study Completion Date2026-08-05

Terms related to this study

Keywords Provided by Researchers

  • Brain
  • Depression

Additional Relevant MeSH Terms

  • Depression