FMRI Accelerated TMS Depression

Description

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Conditions

Depression

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Study Overview

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Study Details

Study overview

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Tracking Brain Imaging Changes in Depression Over Clinical Accelerated Transcranial Magnetic Stimulation (TMS) Therapy At the Individual Level

FMRI Accelerated TMS Depression

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

Charleston

30 Bee Street, Charleston, South Carolina, United States, 29429

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-65
  • * Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
  • * DSM-IV diagnosis of MDD
  • * Unable to speak English.
  • * Contraindicated for MRI.
  • * Any current or recent untreated medical, neurological, or psychiatric conditions
  • * Metal implant devices in the head, heart, or neck.
  • * History of brain surgery.
  • * History of cortisol medication use or electroconvulsive therapy.
  • * Comorbidity with other psychiatric/neurological illnesses or personality disorders
  • * History of myocardial infarction or arrhythmia, bradycardia.
  • * Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
  • * Individuals suffering from frequent/severe headaches.
  • * Moderate to severe alcohol or substance use disorder.
  • * Pregnancy

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical University of South Carolina,

Xiaolong Peng, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2026-08-05