RECRUITING

The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Conditions

Collagen Degeneration Wrinkle Pigmentation Elastic Skin Sebum Deficiency Facial Wrinkles Skin biophysical properties Photoaging

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.

Official Title

Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles

Quick Facts

Study Start:2024-07-22

Study Completion:2025-07-22

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06571721

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:FEMALE

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3 * Individuals with facial fine lines and wrinkles	* Individuals who are pregnant or breastfeeding * Prisoners * Adults unable to consent * Those with a nut allergy or tocopherol allergy * Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes) * Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment: * Retinoids such as tretinoin, adapalene, retinol, except as provided by the study. * Antioxidant ingredients such as vitamin C or vitamin E. * Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study. * Topicals that contain a nut oil or nut extract as part of their ingredient list.

Inclusion Criteria

Exclusion Criteria

* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
* Individuals with facial fine lines and wrinkles

* Individuals who are pregnant or breastfeeding
* Prisoners
* Adults unable to consent
* Those with a nut allergy or tocopherol allergy
* Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
* Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
* Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
* Antioxidant ingredients such as vitamin C or vitamin E.
* Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
* Topicals that contain a nut oil or nut extract as part of their ingredient list.

Contacts and Locations

Study Contact

Nasima Afzal

CONTACT

915-750-2463

nasima@integrativeskinresearch.com

Study Locations (Sites)

Integrative Research Institute

Sacramento, California, 95819

United States

Collaborators and Investigators

Sponsor: Integrative Skin Science and Research

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-22

Study Completion Date2025-07-22

Study Record Updates

Study Start Date2024-07-22

Study Completion Date2025-07-22

Terms related to this study

Keywords Provided by Researchers

Facial Wrinkles
Skin biophysical properties
Photoaging
Pigmentation

Additional Relevant MeSH Terms

Collagen Degeneration
Wrinkle
Pigmentation
Elastic Skin
Sebum Deficiency