The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Eligibility Criteria

• * Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
• * Individuals with facial fine lines and wrinkles
• * Individuals who are pregnant or breastfeeding
• * Prisoners
• * Adults unable to consent
• * Those with a nut allergy or tocopherol allergy
• * Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
• * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
• * Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
• * Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
• * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
• * Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
• * Antioxidant ingredients such as vitamin C or vitamin E.
• * Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
• * Topicals that contain a nut oil or nut extract as part of their ingredient list.