RECRUITING

Breast Cancer PSMA PET

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.

Official Title

Evaluation of PSMA Expression in Triple Negative Breast Cancer Patients Using 18 F-DCFPyL-PET/CT

Quick Facts

Study Start:2024-08-29
Study Completion:2026-08-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06586047

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Female \>= 18 years of age
  2. * Patients in distantly metastatic TNBC based on the initial diagnosis biopsy.
  3. * Patient should have FDG positive metastatic lesions on the initial PET/CT scan performed in this study to be further included.
  1. * Patients with known active other malignancy.
  2. * Unable to tolerate PET/CT procedure.
  3. * Pregnant or breastfeeding.
  4. * Patients with any medical condition that might compromise the safety of subject during PET acquisitions.

Contacts and Locations

Study Contact

Ahmad Shariftabrizi, M.D.
CONTACT
319-887-4942
ashariftabrizi@uiowa.edu
Elina Shrestha
CONTACT
319 335 0114
eshrestha@uiowa.edu

Study Locations (Sites)

University of Iowa Healthcare
Iowa City, Iowa, 52242
United States

Collaborators and Investigators

Sponsor: Ahmad Shariftabrizi

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-29
Study Completion Date2026-08-29

Study Record Updates

Study Start Date2024-08-29
Study Completion Date2026-08-29

Terms related to this study

Keywords Provided by Researchers

  • Breast cancer, PSMA expression, PET imaging

Additional Relevant MeSH Terms

  • Triple Negative Breast Cancer