Breast Cancer PSMA PET

Description

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.

Conditions

Triple Negative Breast Cancer

Study Overview

Study Details

Study overview

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.

Evaluation of PSMA Expression in Triple Negative Breast Cancer Patients Using 18 F-DCFPyL-PET/CT

Breast Cancer PSMA PET

Condition
Triple Negative Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Healthcare, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female \>= 18 years of age
  • * Patients in distantly metastatic TNBC based on the initial diagnosis biopsy.
  • * Patient should have FDG positive metastatic lesions on the initial PET/CT scan performed in this study to be further included.
  • * Patients with known active other malignancy.
  • * Unable to tolerate PET/CT procedure.
  • * Pregnant or breastfeeding.
  • * Patients with any medical condition that might compromise the safety of subject during PET acquisitions.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ahmad Shariftabrizi,

Study Record Dates

2026-08-29