RECRUITING

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

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Conditions

StrokeHemiparesisfunctional magnetic resonance imaging

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Official Title

Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord FMRI in Chronic Hemiparetic Stroke

Quick Facts

Study Start:2025-01-10
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06598150

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults aged at least 18y
  2. * Able to perform shoulder abduction task (confirmed during screening and initial examination)
  3. * Safe to undergo MRI
  4. * Able to follow visual instructions using MRI-compatible vision correction goggles
  5. * No brainstem or cerebellar lesions
  6. * No severe concurrent medical problems (e.g. cardiorespiratory impairment)
  7. * Cognitive/attentional capacity to focus on a task
  8. * Able to communicate in English or Spanish
  9. * Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
  10. * Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).
  1. * MRI contraindications
  2. * Severe claustrophobia
  3. * Pregnant women
  4. * Prisoners
  5. * Vulnerable populations
  6. * Diagnosis/history of:
  7. * multiple sclerosis
  8. * brain tumor
  9. * brain radiation
  10. * traumatic brain injury
  11. * dementia
  12. * Parkinson\'s disease
  13. * emphysema
  14. * chronic obstructive pulmonary disease
  15. * obstructive sleep apnea
  16. * Concurrent enrollment in an intervention study
  17. * Concurrent use of medications known to suppress central nervous system activity

Contacts and Locations

Study Contact

Neha Reddy, BS
CONTACT
3128576864
anvil@northwestern.edu

Principal Investigator

Molly G Bright, DPhil
PRINCIPAL_INVESTIGATOR
Northwestern University

Study Locations (Sites)

Northwestern University
Chicago, Illinois, 60611
United States

Collaborators and Investigators

Sponsor: Northwestern University

  • Molly G Bright, DPhil, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-10
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2025-01-10
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • functional magnetic resonance imaging

Additional Relevant MeSH Terms

  • Stroke
  • Hemiparesis