Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

Description

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Conditions

Stroke, Hemiparesis

Talk to us

Study Overview

On this page

Study Details

Study overview

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord FMRI in Chronic Hemiparetic Stroke

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults aged at least 18y
  • * Able to perform shoulder abduction task (confirmed during screening and initial examination)
  • * Safe to undergo MRI
  • * Able to follow visual instructions using MRI-compatible vision correction goggles
  • * No brainstem or cerebellar lesions
  • * No severe concurrent medical problems (e.g. cardiorespiratory impairment)
  • * Cognitive/attentional capacity to focus on a task
  • * Able to communicate in English or Spanish
  • * Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
  • * Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).
  • * MRI contraindications
  • * Severe claustrophobia
  • * Pregnant women
  • * Prisoners
  • * Vulnerable populations
  • * Diagnosis/history of:
  • * multiple sclerosis
  • * brain tumor
  • * brain radiation
  • * traumatic brain injury
  • * dementia
  • * Parkinson\'s disease
  • * emphysema
  • * chronic obstructive pulmonary disease
  • * obstructive sleep apnea
  • * Concurrent enrollment in an intervention study
  • * Concurrent use of medications known to suppress central nervous system activity

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Northwestern University,

Molly G Bright, DPhil, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

2026-08-31