RECRUITING

White Matter Plasticity in Schizophrenia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Official Title

White Matter Plasticity in Schizophrenia

Quick Facts

Study Start:2025-01-02
Study Completion:2026-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06641297

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:15 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
  2. * age 15-45
  3. * able to provide informed consent
  1. * contraindications to MRI (metal implants, claustrophobia)
  2. * medical condition that limits use of hands (ie, arthritis)
  3. * Active or recent (within 6 months) substance use disorder other than nicotine

Contacts and Locations

Study Contact

Joshua J Chiappelli, MD
CONTACT
4104026827
jchiappe@som.umaryland.edu

Study Locations (Sites)

Maryland Psychiatric Research Center
Catonsville, Maryland, 21228
United States
University of Maryland Baltimore - Maryland Psychiatric Research Center
Catonsville, Maryland, 21228
United States

Collaborators and Investigators

Sponsor: University of Maryland, Baltimore

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-02
Study Completion Date2026-12-31

Study Record Updates

Study Start Date2025-01-02
Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

  • music
  • training
  • plasticity

Additional Relevant MeSH Terms

  • Schizophrenia Disorders