White Matter Plasticity in Schizophrenia

Description

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Conditions

Schizophrenia Disorders

Study Overview

Study Details

Study overview

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

White Matter Plasticity in Schizophrenia

White Matter Plasticity in Schizophrenia

Condition
Schizophrenia Disorders
Intervention / Treatment

-

Contacts and Locations

Catonsville

Maryland Psychiatric Research Center, Catonsville, Maryland, United States, 21228

Catonsville

University of Maryland Baltimore - Maryland Psychiatric Research Center, Catonsville, Maryland, United States, 21228

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
  • * age 15-45
  • * able to provide informed consent
  • * contraindications to MRI (metal implants, claustrophobia)
  • * medical condition that limits use of hands (ie, arthritis)
  • * Active or recent (within 6 months) substance use disorder other than nicotine

Ages Eligible for Study

15 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2026-12-31