RECRUITING

fMRI and Opioid Abstinence

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Conditions

Drug Use DisorderOpioid DependenceOpioid-Related DisordersOpioid UseOpioid AbuseRelapse

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Official Title

Functional Connectivity Mechanisms of Opioid Abstinence

Quick Facts

Study Start:2024-12-12
Study Completion:2029-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06651333

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * recent initiation of methadone or buprenorphine at APT Foundation within the past 6 months (i.e., period of time during which treatment drop-out and risk for relapse is highest);
  2. * eligibility for MRI scanning;
  3. * ability to commit to study visits.
  1. * current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
  2. * current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
  3. * severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \<30 (i.e., severe impairment)
  4. * past or present history of intellectual disability, developmental disorder, or neurological disease;
  5. * head trauma with loss of consciousness \>30 min;
  6. * organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

Contacts and Locations

Study Contact

Monica Holler, BS
CONTACT
203 737 3531
monica.holler@yale.edu

Principal Investigator

Sarah Yip, PhD, MSc
PRINCIPAL_INVESTIGATOR
Yale School of Medicine

Study Locations (Sites)

The APT Foundation
New Haven, Connecticut, 06520
United States

Collaborators and Investigators

Sponsor: Yale University

  • Sarah Yip, PhD, MSc, PRINCIPAL_INVESTIGATOR, Yale School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-12
Study Completion Date2029-11

Study Record Updates

Study Start Date2024-12-12
Study Completion Date2029-11

Terms related to this study

Keywords Provided by Researchers

  • Relapse

Additional Relevant MeSH Terms

  • Drug Use Disorder
  • Opioid Dependence
  • Opioid-Related Disorders
  • Opioid Use
  • Opioid Abuse