fMRI and Opioid Abstinence

Description

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Conditions

Drug Use Disorder, Opioid Dependence, Opioid-Related Disorders, Opioid Use, Opioid Abuse

Study Overview

Study Details

Study overview

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Functional Connectivity Mechanisms of Opioid Abstinence

fMRI and Opioid Abstinence

Condition
Drug Use Disorder
Intervention / Treatment

-

Contacts and Locations

New Haven

The APT Foundation, New Haven, Connecticut, United States, 06520

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * recent initiation of methadone or buprenorphine at APT Foundation within the past 6 months (i.e., period of time during which treatment drop-out and risk for relapse is highest);
  • * eligibility for MRI scanning;
  • * ability to commit to study visits.
  • * current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
  • * current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
  • * severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \<30 (i.e., severe impairment)
  • * past or present history of intellectual disability, developmental disorder, or neurological disease;
  • * head trauma with loss of consciousness \>30 min;
  • * organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Sarah Yip, PhD, MSc, PRINCIPAL_INVESTIGATOR, Yale School of Medicine

Study Record Dates

2029-11