RECRUITING

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

Description

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

Study Overview

Study Details

Study overview

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women and Sheep

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

Condition
Infertility, Female
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado School of Medicine, Aurora, Colorado, United States, 80045

Aurora

University of Colorado-School of Medicine, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-38
  • * Regular menstrual cycles every 25-35 days
  • * No use of reproductive hormones within the past 3 months
  • * No use of medications interacting with reproductive hormones
  • * Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
  • * Normal thyroid stimulating hormone, prolactin and lipid profiles
  • * No more than 4 hours of moderate to vigorous intensity exercise per week
  • * No history of chronic disease impacting reproductive hormones
  • * No contraindications to administration of estradiol
  • * No history of estrogen dependent cancer
  • * Negative pregnancy test
  • * Has diabetes
  • * Is a smoker
  • * History of venous thromboembolism or known thrombophilia

Ages Eligible for Study

18 Years to 38 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Colorado, Denver,

Nanette Santoro, MD, PRINCIPAL_INVESTIGATOR, University of Colorado School of Medicine

Study Record Dates

2026-12