RECRUITING

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

Official Title

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women and Sheep

Quick Facts

Study Start:2025-02-25
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06686537

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 38 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-38
  2. * Regular menstrual cycles every 25-35 days
  3. * No use of reproductive hormones within the past 3 months
  4. * No use of medications interacting with reproductive hormones
  5. * Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
  6. * Normal thyroid stimulating hormone, prolactin and lipid profiles
  7. * No more than 4 hours of moderate to vigorous intensity exercise per week
  8. * No history of chronic disease impacting reproductive hormones
  9. * No contraindications to administration of estradiol
  10. * No history of estrogen dependent cancer
  11. * Negative pregnancy test
  1. * Has diabetes
  2. * Is a smoker
  3. * History of venous thromboembolism or known thrombophilia

Contacts and Locations

Study Contact

Katherine Kuhn
CONTACT
303-724-5276
Katherine.Kuhn@cuanshcutz.edu

Principal Investigator

Nanette Santoro, MD
PRINCIPAL_INVESTIGATOR
University of Colorado School of Medicine

Study Locations (Sites)

University of Colorado School of Medicine
Aurora, Colorado, 80045
United States
University of Colorado-School of Medicine
Aurora, Colorado, 80045
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

  • Nanette Santoro, MD, PRINCIPAL_INVESTIGATOR, University of Colorado School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-25
Study Completion Date2026-12

Study Record Updates

Study Start Date2025-02-25
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Obesity
  • Infertility
  • Hypothalamic-pituitary-ovarian axis
  • pituitary dysfunction

Additional Relevant MeSH Terms

  • Infertility, Female
  • Obesity